Skip to main content
. 2020 May 27;21(11):3817. doi: 10.3390/ijms21113817

Figure 5.

Figure 5

EPO induces irreversible changes in the microarchitecture of the lumbar spine vertebrae. (a) Trabecular bone volume (BV/TV) and trabecular number (Tb.N) of the edge (a) and midportion (b) of the L3 vertebra from diluent (DIL) and EPO (540 IU/week)-treated female mice at the completion of the treatment period and 2, 4 and 6 weeks post treatment. Values are mean ± SD. *** p < 0.001; ** p < 0.01; * p < 0.05; (c) Representative 3D reconstruction images of the L3 vertebra (subdivided into edge- and midportions) of the mice described in (a,b). n = 6 for each group. “Edge” and “middle” portions of the vertebral body were defined as marginal (upper/lower) and middle 1/3 of the vertebral body in the axial plane.