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Compound L3 significantly inhibited DENV-2 or ZIKV compared to other tyrosine kinase inhibitors. HEK-293 cells were infected with DENV-2 (A,B) or ZIKV (C,D) and treated with 10 μM of either compound L3 or the indicated drugs for 36 h. Viral protein expression (A,C) and virus titers (B,D) were analyzed and adjusted to those of the solvent control. Data are the mean ± SD of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 according to a two-tailed Student’s t-test.
