Figure 5.
Compound L3 exhibited protective efficacy in vivo. AG129 mice were infected with 107 focus-forming unit (FFU) of DENV-2 and treated orally with 5 or 10 mg/kg of compound L3 daily for 7 days. (A) Survival rates were determined for 30 days. The number of animals (n) in each group is shown. The data are representative results of three independent experiments. * p < 0.05. (B) Mouse sera were collected on day 3 after treatment. A focus-forming assay was used to measure DENV-2 viremia. Data are the mean ± SD of three independent experiments. ** p < 0.01, *** p< 0.001 according to a two-tailed Student’s t-test.