Figure 4.

Both inhibition and activation of TRPA1 channels affect Ca²⁺ signals in MRC-5 cells. Traces show representative Ca²⁺ responses recorded in MRC-5, before and after acute application of one of the investigated compounds: (A) 832 (10 µM), n = 22; (B) 869 (10 µM), n = 23; (C) 145 (10 µM), n = 28; (D) HC-030031 (10 µM), n = 25; (E) ASP7663 (10 µM), n = 23. (F) Fold change of TRPA1 inhibition or activation after an acute application of investigated compounds.