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Compounds 832, 869, and 145 as TRPA1 modulators.
| Compound | TRPA1 Inhibition (% of control) | TRPA1 Activation (% of Control) | ||
|---|---|---|---|---|
| 10 µM | 50 µM | 10 µM | 50 µM | |
| 832 | 12.4 | 8.8 | 3.8 | 2.4 |
| 869 | 74.9 | 98.7 | 0.0 | 2.2 |
| 145 | 12.3 | 4.8 | 0.2 | 4.6 |
| HC-030031 | 91.8 | 98.8 | - | - |
| ASP 7663 | - | - | 75.8 | 76.1 |
