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. 2020 Jun 11:1–12. doi: 10.1080/07391102.2020.1776157

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Figure 2. — Curcuma longa lead phytochemical interaction with SARS-CoV2 M^pro protein. (A) Surface structure of M^pro protein interacted with lead compound C1 (1E,6E)-1,2,6,7-tetrahydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione). Green color represents the mentioned amino acid involved in hydrogen bonding. (B) Ligplot representation of lead compound C1 and Mpro protein (C) Curcuma longa lead phytochemical C2 (4Z,6E)‐1,5‐dihydroxy‐1,7‐bis(4‐hydroxyphenyl)hepta‐4,6‐dien‐3‐one) bound with SARS-CoV2 main protease M^pro. Green color represents the mentioned amino acid involved in hydrogen bonding. (D) Ligplot representation of compound C2 and M^pro protein. (E) Surface structure with superimposed Curcuma longa phytochemicals C1 (red color) and C2 (magenta color) and standard inhibitor lopinavir (cyan color). (F) Ligplot representation of standard inhibitor lopinavir with SARS-CoV2 main protease M^pro.