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. 2020 Jun 2;21(11):3992. doi: 10.3390/ijms21113992

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Normalized extra-tension in young and elderly subjects. Left: the same fraction (α=3.3%) of ECM in CSA is considered in the two groups. Right: fraction of ECM (parameter α) is imposed at 3.3% of fibers CSA in young subjects and 8.2% in elderly subjects. Data are shown as mean value +/- SEM. The differences between elderly and young subjects at each sarcomere length level of the left histogram are statistically significant (p < 0.05), while the same differences in the right histogram are not.