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. 2020 Jun 3;21(11):3998. doi: 10.3390/ijms21113998

Figure 2.

Figure 2

Gene expression analyses of Phase I, II and III related genes of 3D- and 2D-HLCs after 3 (D27) and 10 days (D34) of NVP treatment. (A) Gene expression of Phase I enzymes comprising CYP3A4, CYP2B6 and CYP2D6 in NVP-treated cells relative to non-treated cells. (B) Gene expression of Phase II enzymes comprising SULT1A1, UGT1A1 and GSTA1-A2 in NVP-treated cells relative to non-treated cells. (C) Gene expression of the MRP7 transporter in NVP-treated cells relative to non-treated cells. (A–C) Data for hnMSC exposed to NVP for 3 days and used as negative controls, are also shown. (D) Phase I, II and III gene expression in 3D-HLCs relative to 2D-HLCs in NVP-treated cells at D27 and D34. The data (Mean ± SD, n = 3) are normalized to the reference gene β-ACTIN and expressed as the log10 of the ratios.