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. 2020 Jun 3;21(11):3998. doi: 10.3390/ijms21113998

Figure 6.

Figure 6

Glutathiolomic analysis of 3D- and 2D-HLCs treated or non-treated with NVP. (A) Effect of NVP on glutathione synthesis and degradation ratios, after 3 (D27) and 10 days (D34) of NVP treatment; (B) Effect of NVP on total intracellular availability for cysteine (Cys), glutamylcysteine (GluCys) and glutathione and total extracellular levels of cysteinylglicine (CysGly) and glutathione, in 3D-HLCs, after 3 (D27) and 10 days (D34) of NVP treatment; (C) NVP effect on intracellular levels of protein-bound glutathione (GSSP) and free glutathione, after 3 (D27) and 10 days (D34) of NVP treatment; (D) NVP effect on glutathione oxidation (intracellular GSH/GSSG ratio) after 10 days of NVP treatment (D34). * p < 0.05, ** p < 0.01 and *** p < 0.001 relative to 2D-HLCs. The data are represented as Mean ± SD, n = 3.