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. 2020 May 27;21(11):3800. doi: 10.3390/ijms21113800

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) The cell viability in KMS-12 PE cells exposed to various concentrations of CBD for 24 h: The results of the CCK8 assay did not show any significant difference compared to the DMSO control (p > 0.5). (B) The cytotoxicity in in KMS-12 PE cells exposed to various concentrations of CBD for 24 h: The results of the LDH assay showed a significant decrease of the LDH release at 3 µM (p ≤ 0.001) and 10 µM (p < 0.05) compared to the DMSO control. However, the results showed a significant increase at 15 µM (p < 0.05) and 20 µM (p ≤ 0.001) compared to the DMSO control.