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. 2020 Jun 5;21(11):4065. doi: 10.3390/ijms21114065

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Plasma membrane expression of TMEM16E, -H, -J or -K was not correlated to phospholipid scrambling activity. (A) CFP fluorescence (green) of living HEK293 cells transfected with TMEM16E-CFP-CAAX, (B) TMEM16H-CFP-CAAX, (C) TMEM16J-CFP-CAAX or (D) TMEM16K-CFP-CAAX was mostly not localized with the annexin V signal (red), indicating absence of phosphatidylserine scrambling to the outer leaflet of the plasma membrane under control and after stimulation with ionomycin. Bar 20 µm. (E) Summary of positive cells for TMEM16 paralogs and annexin V staining under control (con) and stimulated (iono) conditions. (Number of experiments), # unpaired t-test, and analysis of variance (ANOVA), α < 0.05.

Plasma membrane expression of TMEM16E, -H, -J or -K was not correlated to phospholipid scrambling activity. (A) CFP fluorescence (green) of living HEK293 cells transfected with TMEM16E-CFP-CAAX, (B) TMEM16H-CFP-CAAX, (C) TMEM16J-CFP-CAAX or (D) TMEM16K-CFP-CAAX was mostly not localized with the annexin V signal (red), indicating absence of phosphatidylserine scrambling to the outer leaflet of the plasma membrane under control and after stimulation with ionomycin. Bar 20 µm. (E) Summary of positive cells for TMEM16 paralogs and annexin V staining under control (con) and stimulated (iono) conditions. (Number of experiments), # unpaired t-test, and analysis of variance (ANOVA), α < 0.05.