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. 2020 Jun 5;21(11):4065. doi: 10.3390/ijms21114065

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Reduced P2X7R-dependent membrane blebbing in cells expressing TMEM16 paralogs. (A) HEK293 cells were transfected with CFP (control), P2X7 receptor (P2X7R) and CFP or P2X7R and TMEM16 paralogs in a ratio of 4:1. Membrane blebbing was stimulated by 5 mM ATP. Blebbing events were counted in a time frame of 15 min after addition of ATP. Bar 20 µm. White arrows indicate blebbing events. (B) Summary of membrane blebbing rate (blebbing/min) of HEK293 cells expressing CFP (control), P2X7R and CFP or P2X7R and TMEM16 paralogs. Mean ± SEM (Number of experiments). For each experiment 10 CFP positive cells were measured), # significant difference when compared to control (ANOVA), α < 0.05.

Reduced P2X7R-dependent membrane blebbing in cells expressing TMEM16 paralogs. (A) HEK293 cells were transfected with CFP (control), P2X7 receptor (P2X7R) and CFP or P2X7R and TMEM16 paralogs in a ratio of 4:1. Membrane blebbing was stimulated by 5 mM ATP. Blebbing events were counted in a time frame of 15 min after addition of ATP. Bar 20 µm. White arrows indicate blebbing events. (B) Summary of membrane blebbing rate (blebbing/min) of HEK293 cells expressing CFP (control), P2X7R and CFP or P2X7R and TMEM16 paralogs. Mean ± SEM (Number of experiments). For each experiment 10 CFP positive cells were measured), # significant difference when compared to control (ANOVA), α < 0.05.