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Frequency of contacts at the determined allosteric site in the holo (left sub-figure) and the ligand-bound complexes (right sub-figure). The allosteric site residue is shown in the middle of each contact map while residues at the Z-domain are circled in red. (A) Contact frequency between Gln395, Thr706 and Leu707, (B) Contact frequency between Arg472 and Ser708, (C) Contact frequency between Arg744 and Gly709 and (D) Contact frequency between Ser745 and Ser708.
