Table 4.

Residues with significant changes in average L (2 standard deviations away). Residues at the active site are shown in green, residues at the ATP binding site in purple and residues at the Z-domain in magenta.

Protein-Ligand Complex	Residues with Significant Decrease in Average L in the Orthosteric Ligand Complexes	Residues with Significant Increase in Average L in the Orthosteric Ligand Complexes
PfProRS-SANC152	333, 260, 335, 363, 362, 310, 552, 308, 307, 334, 303, 386, 338, 311, 300, 309	705, 707, 706, 708, 281, 319, 699, 700, 573, 553, 349
PfProRS-SANC235	552, 709, 338, 334, 335, 333, 327, 386, 337, 363, 362, 546, 336, 339	706, 707, 705, 579, 703, 700
PfProRS-SANC236	552, 338, 333, 701, 339, 334, 335, 336, 337, 395, 709, 711, 332, 710, 393, 394	703,705, 707, 704, 706, 698, 319, 700, 702, 314, 316
PfProRS-SANC244	550, 551, 709, 552, 401, 711, 546	707, 706, 703, 705, 349, 702, 368, 347, 700, 704
PfProRS-SANC318	552, 709, 395, 260, 701, 396, 551, 393, 401, 338, 394, 259, 402, 339	705, 707, 703, 328, 704, 319, 316, 281, 702
Protein- Ligand Complex	Residues with Significant Decrease in Average L in the Allosteric Ligand Complexes	Residues with Significant Increase in Average L in the Allosteric Ligand Complexes
PfProRS-SANC184	333, 349, 335, 334, 345, 347, 338, 348, 343, 350, 310, 344, 455, 337, 336, 456, 363, 331, 346, 330, 311	704, 701, 705, 702, 703, 707, 553, 700, 708, 264, 550
PfProRS-SANC257	333, 455, 334, 456, 738, 332, 460, 457, 308	701, 702, 705, 708, 706, 704, 703, 709, 553, 552, 707,396, 700, 550
PfProRS-SANC264	349, 347, 348, 346, 455, 345, 260, 572, 571, 570	704, 705, 708, 702, 703, 709, 701, 328, 553, 327, 330, 331, 707, 706, 552, 264, 265
PfProRS-SANC456	260, 333, 334, 335, 328, 455, 485, 570	701, 708, 705, 702, 707, 706, 704, 709, 396, 316, 703, 553, 319, 550, 264, 265, 268, 700
PfProRS-SANC622	260, 455, 310, 308, 254, 311, 486, 460	701, 702, 704, 706, 707, 703, 341, 708, 339, 319, 705, 338, 709, 346, 347, 342, 348, 343, 345, 344