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. 2020 Jun 9;21(11):4116. doi: 10.3390/ijms21114116

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Summary of new therapeutic stategies, combined to counteract ERα36-dependent resistance to hormone therapy in breast cancer. Since ERα36 expression/ activity is stimulated by tamoxifen and cisplatin but down-regulated by broussoflavonol or Icaritin, decitabine and some micro-RNA overexpression, a dietary administration of flavonoids combined to anti-cancer strategy based on both hormone therapy and demethylating agents could prevent the emergence of ERα36-dependent resistance to hormone therapy in luminal breast tumors.