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Virulence factors of mycobacteria. Three type VII secretion systems—ESAT-6 secretion system-1 (ESX-1), ESX-3, and ESX-5—secrete proteins across the IM. Pro-Glu (PE)/Pro-Pro-Glu (PPE) small-molecule selective channels transport nutrients and proteins across the OM. Various mycobacterial cell wall lipids are depicted on the outer leaflet of the OM. Inner membrane (IM); peptidoglycan (PG); outer membrane (OM).
