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. 2020 Jun 2;21(11):3986. doi: 10.3390/ijms21113986

Figure 6.

Figure 6

TBP DNA-binding motif interacting with the extremely widened minor groove. The contacted DNA sequence consists only of AT base pairs (green). Two phenylalanine residues (orange) intercalate into the helix on one or both edges of the motif (detail on the right). A similar DNA-contacting motif appears in the dataset also in 4ROC and 1YTB structures, both containing similar extreme deformations of the minor groove in AT-rich sequences.