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. 2020 Jun 14;2020:2806042. doi: 10.1155/2020/2806042

Figure 5.

Figure 5

Knockdown of RP11-838N2.3 could inhibit proliferation efficiency of A549/DDP. (a) Compared with that of 0 h, OD450mn of 24 h (P < 0.001, P < 0.001, P < 0.001, and P < 0.001), 48 h (P < 0.001, P < 0.001, P < 0.001, and P < 0.001), and 72 h (P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P = 0.001) significantly reduced. Compared with the A549/DDP shRNA-NC group, the OD450mn of the A549/DDP shRNA group in 24 h (F = 1.101, P = 0.002), 48 h (F = 0.525, P < 0.001), and 72 h (F = 0.889, P < 0.001) plainly reduced. (b) Under the action of cisplatin drugs, RP11-838N2.3 gene knockdown can still obviously inhibit the proliferation of A549/DDP. Compared with the A549/DDP shRNA-NC+2 μg/ml cisplatin group, the OD450mn of the A549/DDP shRNA+2 μg/ml cisplatin group in 24 h (F = 0.130, P = 0.001), 48 h (F = 1.482, P = 0.001), and 72 h (F = 0.006, P < 0.001) significantly reduced. ∗P < 0.05; ∗∗P < 0.01.