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. 2020 Jun 14;2020:2806042. doi: 10.1155/2020/2806042

Figure 7.

Figure 7

Knockdown of RP11-838N2.3 could inhibit proliferation efficiency of A549/DDP. (a) Compared with that of 0 h, the relative widths of 24 h (P < 0.001, P < 0.001, P < 0.001, and P < 0.001), 48 h (P < 0.001, P < 0.001, P < 0.001, and P < 0.001), 72 h (P < 0.001, P < 0.001, P < 0.001, and P < 0.001) decreased obviously and the mobility increased evidently. Compared with that of the A54/DDP shRNA-NC group, the relative widths of the A549/DDP shRNA group in 24 h (F = 0.007, P < 0.001), 48 h (F = 0.914, P < 0.001), and 72 h (F = 0.007, P < 0.001) increased obviously, and the mobility decreased clearly. These results showed that RP11-838N2.3 knockdown obviously inhibited the migration of A549/DDP cells. (b) Under the action of cisplatin drugs, RP11-838N2.3 knockdown can still clearly inhibit the migration of A549/DDP cells. Compared with that of the A549/DDP shRNA-NC+2 μg/ml cisplatin group, the relative widths of the A549/DDP shRNA+2 μg/ml cisplatin group in 24 h (F =2.129, P < 0.001), 48 h (F =2.919, P < 0.001), and 72 h (F =5.460, P <0.001) increased clearly. ∗∗∗P < 0.01.