Figure 9.

Knockdown of RP11-838N2.3 could inhibit invasion ability of A549/DDP (a) A549/DDP shRNA-NC. (b) A549/DDP shRNA. (c) A549/DDP shRNA-NC+2 μg/ml cisplatin. (d) A549/DDP shRNA+2 μg/ml cisplatin. (e) Compared with that of the A549/DDP shRNA-NC group, the relative invasion rate of the A549/DDP shRNA group was obviously reduced (F = 2.091, P < 0.001). Under the action of cisplatin drugs, RP11-838N2.3 gene knockdown can still distinctly inhibit the invasion of A549/DDP cells. Compared with that of the A549/DDP shRNA-NC+2 μg/ml cisplatin group, the relative invasion rate of the A549/DDP shRNA+2 μg/ml cisplatin group still decreased clearly (F = 0.248, P < 0.001). ∗∗∗P < 0.001.