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DNA methylation in isolated hepatocytes. (A) Methylation state of the mouse Igfbp2 promoter (position 2912, sequence ID: AC121498.12), (B) activity of methyltransferases, and (C) sirtuins (SIRT) in hepatocyte whole-cell lysates from C57Bl6 (C57), alb-SREBP-1c (alb), and aP2-SREBP-1c (aP2) mice. Data are expressed as mean (±95% CI; n = 4–8). Statistics: ANOVA with Sidak correction: ** p < 0.01 and * p < 0.05. RLU: relative luminescence units.
