Figure 2.

Enzymatic regulation of epigenetic histone modifications most relevant in diabetic nephropathy. (A) Lysine mono-, di- or tri- methylation is mediated by lysine methyl-transferases (KMT) and demethylation by lysine demethylases (KDM). (B) Histone acetylation, crotonylation and β-hydroxybutyrylation share some enzymes such as the histone acyl transferase CBP and combinations of p300 and MOF, and some histone deacetylases (HDACs) that may also remove other acyl groups. CBP: CREB-binding protein; MOF: Males absent on the first.