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PHLDA3-deficient mice exhibit islet hyperplasia and resistance of β cells to apoptosis. (A) HE staining of islets from wild type and PHLDA3-deficient 10 month-old mice. (B) Apoptosis of β cells is observed in wild type mice treated with streptozotocin (STZ) but is suppressed in PHLDA3-deficient mice.
