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A model of NET tumorigenesis resulting from functional loss of both PHLDA3 and MEN1. PHLDA3 is a repressor of Akt. Loss of PHLDA3 leads to Akt activation, increased cell proliferation and decreased apoptosis. PHLDA3 functions independent of MEN1, and PanNET tumorigenesis therefore requires the functional loss of both PHLDA3 and MEN1.
