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Proposed molecular mechanisms of anticancer action of α-mangostin glycosides in HCC cells. The α-mangostin glycosides, Man-3DG and Man-6DG, may exhibit potent anticancer and antiangiogenic activities against HCC cells by downregulating c-Met, HIF-1α, and cancer stemness regulators. In addition, the combination with autophagy inhibitor can be a promising strategy for improving the anticancer effects of α-mangostin glycosides against HCC.
