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. 2020 Jun 9;21(11):4109. doi: 10.3390/ijms21114109

Figure 2.

Figure 2

Inflammatory airway hyperreactivity: (A) carbachol-induced bronchoconstriction and (B) changes in breathing frequency. Carbachol-evoked bronchoconstriction remarkably increased, and the decrease in breathing frequency was significantly greater in Trpa1−/− mice 24 h after LPS administration, but not in the wildtypes. Values represent the means ± SEM, n = 5–10 mice/group; two-way ANOVA followed by Tukey’s post-test; + p < 0.05, ++ p < 0.005, +++ p < 0.001 vs. PBS-treated respective group; * p < 0.05 vs. LPS-treated Trpa1+/+.