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MSU-induced ROS originate from the NADPH-oxidase. (A) Neutrophils pre-treated with the NADPH-oxidase inhibitors DPI (10 µg/mL) or GSK (20 µg/mL) did not produce icROS in response to MSU crystals (300 μg/mL); peak values +/− SD are shown (n = 3). (B) Neutrophils from a patient with CGD (broken line) did not produce icROS in response to MSU crystals (300 µg/mL) as compared to control neutrophils (solid line). Arrows indicate addition of stimuli.
