. 2020 Jun 10;21(11):4147. doi: 10.3390/ijms21114147

Table 1.

Summary of meta-analysis on microRNAs (miRNA) expression between microarray and real-time polymerase chain reaction (RT-PCR).

Periodontal Health vs. Periodontitis (Humans)
miRNA	Lab Test	Fold.Dif	SE	CI 95%	p-Value	I²
miR 24-3p	Microarray	0.58	0.29	0.00 1.16	0.049*	62.0%
miR 24-3p	RT-PCR	N/A	N/A	N/A	N/A	N/A
miR 27b-3p	Microarray	0.05	0.22	−0.37 0.48	0.803	93.1%
miR 27b-3p	RT-PCR	N/A	N/A	N/A	N/A	N/A
miR 30e	Microarray	2.34	1	0.37 4.31	0.020*	60.5%
miR 30e	RT-PCR	N/A	N/A	N/A	N/A	N/A
miR 130a	Microarray	2.84	0.82	1.23 4.44	<0.001***	0.0%
miR 130a	RT-PCR	N/A	N/A	N/A	N/A	N/A
miR 132	Microarray	0.75	1.22	−1.65 3.15	0.538	85.1%
miR 132	RT-PCR	N/A	N/A	N/A	N/A	N/A
miR 142-3p	Microarray	2.71	0.39	1.94 3.47	<0.001***	0.0%
miR 142-3p	RT-PCR	2.54	0.93	0.72 4.53	0.006**	54.8%
miR 144	Microarray	1.97	0.37	1.24 2.71	<0.001***	0.0%
miR 144	RT-PCR	N/A	N/A	N/A	N/A	N/A
miR 146a	Microarray	1.56	0.54	0.49 2.63	0.004**	0.0%
miR 146a	RT-PCR	3.48	1.35	0.84 6.12	0.010*	86.9%
miR 155	Microarray	−0.01	1.7	−3.34 3.32	0.995	88.1%
miR 155	RT-PCR	0.72	2.7	−4.57 6.01	0.79	91.4%
miR 210	Microarray	0.72	0.24	0.25 1.18	0.002**	9.8%
miR 210	RT-PCR	0.33	0.8	−1.23 1.89	0.681	87.9%
miR 223	Microarray	2.51	0.46	1.60 3.42	<0.001***	0.0%
miR 223	RT-PCR	4.73	3.09	−1.34 10.8	0.127	90.0%
**Periodontal health vs. Periodontitis (Animals)**
miRNA	Lab test	Fold.Dif	SE	CI 95%	p-value	I²
miR 132	Microarray	N/A	N/A	N/A	N/A	N/A
miR 132	RT-PCR	0.17	0.47	−0.76 1.09	0.726	47.70%
miR 146a	Microarray	N/A	N/A	N/A	N/A	N/A
miR 146a	RT-PCR	1.2	0.75	−0.27 2.66	0.109	88.40%
miR 155	Microarray	N/A	N/A	N/A	N/A	N/A
miR 155	RT-PCR	1.54	0.71	0.14 2.94	0.031*	74.20%
**Peri-implant health vs. Peri-implantitis (Animals)**
miRNA	Lab test	Fold.Dif	SE	CI 95%	p-value	I²
let-7g	Microarray	N/A	N/A	N/A	N/A	N/A
let-7g	RT-PCR	−1	0.28	−2	<0.001***	0.00%
miR 27a	Microarray	N/A	N/A	N/A	N/A	N/A
miR 27a	RT-PCR	−0.4	0.12	−0.8	<0.001***	0.00%
miR 29a	Microarray	N/A	N/A	N/A	N/A	N/A
miR 29a	RT-PCR	−0.23	0.09	−0.45	0.001**	0.00%
miR 142	Microarray	N/A	N/A	N/A	N/A	N/A
miR 142	RT-PCR	−0.36	0.16	−0.72	0.022*	0.00%
miR 145	Microarray	N/A	N/A	N/A	N/A	N/A
miR 145	RT-PCR	1.13	0.32	0.50 1.76	<0.001***	0.00%

Fold.Dif: fold difference, SE: standard error, CI: confidence interval, N/A: not available.