Figure 1.

MicroCT analysis of WT and Il1rn^−/− mice showed no differences in bone microstructure independently of the skeletal site. To assess possible bone destruction at the different skeletal sites, various 3-D microstructural bone parameters, including bone volume fraction (BV/TV), specific bone surface (BS/BV), trabecular thickness (Tb.Th.), and trabecular separation (Tb.Sp.), were measured in all specimens from Il1rn^−/− mice and wild-type (WT) controls (A–D) (n = 3 mice/group). These parameters were comparable between the two mouse strains irrespective of the bone site, suggesting that these Il1rn^−/− mice did not develop structural pathology yet.