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. 2020 May 27;21(11):3774. doi: 10.3390/ijms21113774

Figure 2.

Figure 2

Absence of IL-1RA increases the percentage of myeloid blasts in long bone, and the percentage of monocytes in long bone and jaw. Percentage of early blasts, myeloid blasts, and monocytes from long bone (A), calvaria (B), vertebra (C), and jaw (D) were quantified and compared between wild-type (WT) (black bars) and Il1rn−/− (white bars) mice (n = 6, *p < 0.05 **p < 0.01, ***p < 0.001). Whereas the calvaria and vertebral bone marrow (BM) of Il1rn−/− mice showed no significant differences in the percentage of various osteoclast precursor subsets, we found a significant increase of both the myeloid blasts and monocyte subsets in the BM of long bone. Similarly, the monocyte subset of OCPs was also significantly increased in the jaw BM of Il1rn−/− mice as compared to WT controls.