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Graphical summary of adenovirus-mediated method for genome editing in quail. After designing guide RNA complement to target sequence in the exon of targeted gene, an adenovirus containing CRISPR/Cas9 system is produced. Then, the adenovirus is injected into the subgerminal cavity of quail blastoderm, and potential germ-line chimeric quail are produced. Subsequently, +/+ and +/− offspring are generated, and +/+, +/−, and −/− quail are produced from +/− parents.
