Table 1.

Metabolic end points and brain nicotinamide adenine dinucleotide (NAD⁺) levels in Diabetic (Dia) and Non-Diabetic (Non-Dia) rats + nicotinamide mononucleotide (NMN) (100 mg/day).

Metabolite	Non-Dia (n = 6) 1	Dia (n = 6) 2	Non-Dia + NMN (n = 6) 3	Dia + NMN (n = 6) 4	1 vs. 2	2 vs. 4	1 vs. 3	3 vs. 4	1 vs. 4
Body Weight (g)	416 ± 26	318 ± 21	421 ± 32	296 ± 14	<0.05	NS	NS	<0.05	<0.05
Glucose (mM)	6.1 ± 0.6	22.7 ± 2	6 ± 0.4	24.6 ± 1.3	<0.001	NS	NS	<0.001	<0.001
Cholesterol (mg/dL)	172 ± 14	166 ± 14	165 ± 12	163.4 ± 22	NS	NS	NS	NS	NS
Triglycerides (mg/dL)	185 ± 6	120 ± 3	177 ± 8	124 ± 6	<0.001	NS	NS	<0.001	<0.001
GTT-AUC (mg/dL/min)	10472 ± 200	30030 ± 300	9989 ± 190	29854 ± 278	<0.001	NS	NS	<0.001	<0.001
Brain NAD+ (pmol/mg)	200 ± 15	123 ± 15	237 ± 13	198 ± 12	<0.05	<0.05	NS	<0.05	NS

Data represent the mean value ± SEM. GTT-AUC = glucose tolerance test-area under the curve; NS = not significant.