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. 2020 May 29;21(11):3866. doi: 10.3390/ijms21113866

Figure 7.

Figure 7

β-funaltrexamine alleviated cerebral I/R-induced neurotoxic cytokine production. Rats receiving normal saline vehicle or β-funaltrexamine (82.5 nmol/30 μL) intracerebroventricular infusion were subjected to both CCAs and the right MCA occlusion for 90 min followed by 24-h reperfusion. Total homogenates (ipsilateral and contralateral cortical tissues) were subjected to Griess reagent or ELISA for the measurement of NO (A), TNF-α (B), IL-1β (C), and PGE2 (D) content. Total cellular RNAs were isolated from the ipsilateral and contralateral cortical tissues and subjected to quantitative RT-PCR for the measurement of CD163 (E) and arginase 1 (F) mRNA content. * p < 0.05 vs. the contralateral tissues of the vehicle groups and # p < 0.05 vs. the ipsilateral tissues of the vehicle groups, n = 6.