Table 2.

Body composition during the 3-year study

	At start	After 1 year	After 2 years	After 3 years	P-value*
Total group
Total body FM% (SDS)	2.1 (1.9 to 2.3)	2.0 (1.9 to 2.2)	2.0 (1.8 to 2.1)	1.9 (1.8 to 2.1)	0.012
Total body FM%	39.6 (36.7 to 42.6)	39.4 (36.7 to 42.1)	39.0 (36.4 to 41.6)	38.9 (36.2 to 41.6)	0.37
Total body LBM (SDS)	−2.1 (−2.4 to −1.8)	− 2.0 (− 2.3 to − 1.7)	−1.9 (− 2.3 to − 1.6)	−1.9 (− 2.3 to − 1.6)	0.15
Total body LBM (kg)	39.8 (37.4 to 42.2)	40.7 (38.4 to 43.0)	41.2 (38.8 to 43.5)	40.7 (38.4 to 43.0)	0.17
BMI SDS	0.9 (0.5 to 1.3)	0.9 (0.5 to 1.3)	0.9 (0.5 to 1.3)	0.9 (0.5 to 1.2)	0.60
BMI PWS SDS	−1.6 (−1.9 to − 1.2)	−1.6 (− 2.0 to − 1.2)	−1.7 (− 2.0 to − 1.3)	−1.7 (− 2.1 to − 1.3)	0.08
IGF-I SDS	1.3 (1.0 to 1.6)	1.5 (1.1 to 1.9)	1.2 (0.8 to 1.6)	1.2 (0.8 to 1.6)	0.49

Data are expressed as estimated means (95% CI). FM SDS, FM% SDS and LBM SDS were calculated according to age- and sex-matched Dutch references [25]

*P-value of the change during 3 years of GH treatment