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An illustration of the anti-self-renewal activity of WP1130 and its effect on WT1 protein. a Overexpression of WT1 in leukemia cells contributes to the proliferation and self-renewal of LIC by positively regulating BCL2L2 expression. b WP1130 treatment enhances the ubiquitination of WT1 protein, leading to its degradation via the ubiquitin–proteasome pathway in leukemic cells. The downregulation of WT1 reduces the proliferation and self-renewal of LIC via inhibition of BCL2L2 expression
