Table 4.

Age- and multivariable-adjusted HRs for prostate cancer according to WC stratified by BMI

					HR (95% confidence interval)
BMI, kg/m2	WC, cm	Event	Person-years	Incidencea	Model 1b	Model 2c
<  18.5	WC < 85	462	318,733	144.95	Ref.	Ref.
	85 ≤ WC < 90	4	4018	99.55	0.47 (0.18, 1.26)	0.48 (0.18, 1.27)
	90 ≤ WC < 95	0	0	0	–	–
	95 ≤ WC	0	0	0	–	–
18.5–22.9	WC < 85	6033	4,138,307	145.75	Ref.	Ref.
	85 ≤ WC < 90	1086	594,059	182.81	1.16 (1.09, 1.24)	1.12 (1.05, 1.20)
	90 ≤ WC < 95	196	94,269	207.91	1.14 (0.99, 1.31)	1.03 (0.89, 1.20)
	95 ≤ WC	23	14,442	159.26	0.81 (0.54, 1.22)	0.72 (0.47, 1.11)
23.0–24.9	WC < 85	2874	2,046,401	140.44	Ref.	Ref.
	85 ≤ WC < 90	2638	1,544,705	170.78	1.08 (1.03, 1.15)	1.09 (1.03, 1.15)
	90 ≤ WC < 95	1065	542,265	196.39	1.04 (0.97, 1.12)	1.05 (0.98, 1.13)
	95 ≤ WC	198	85,297	232.13	0.99 (0.86, 1.15)	0.98 (0.85, 1.14)
25.0–29.9	WC < 85	904	703,159	128.56	Ref.	Ref.
	85 ≤ WC < 90	2150	1,601,586	134.24	1.01 (0.93, 1.09)	1.01 (0.93, 1.09)
	90 ≤ WC < 95	2665	1,714,191	155.27	1.04 (0.96, 1.12)	1.03 (0.95, 1.11)
	95 ≤ WC	1841	1,020,521	180.39	1.03 (0.95, 1.11)	1.01 (0.93, 1.09)
≥ 30	WC < 85	0	0	0	–	–
	85 ≤ WC < 90	0	0	0	–	–
	90 ≤ WC < 95	63	47,291	133.22	Ref.	Ref.
	95 ≤ WC	382	272,054	140.41	0.93 (0.71, 1.21)	0.92 (0.69, 1.21)

BMI body mass index, WC waist circumference, HR hazard ratio

^aAll rates are expressed as number per 100,000 person-years

^bAdjusted for age

^cAdjusted for age, diabetes, hypertension, dyslipidemia, smoking status, and alcohol consumption