Fig. 2.

MBDA Scores in PDA, IR and SR states. a–c Baseline MBDA scores. d–f Time-integrated MBDA scores. Patients were grouped with remission defined in a and d by DAS28, in b and e by SDAI and in c and f by ACR/EULAR Boolean criteria. Patient numbers in each group are the same as in Tables 4 and 5. Level of significance determined by Mann-Whitney U test. Values expressed as medians with IQR. PDA, persistent disease activity, i.e. no remission by any criteria at any visit; IR, intermittent remission; SR sustained remission. Levels of significance determined by Mann-Whitney test (NR vs IR, IR vs SR, NR vs SR). ns = p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001