Table 1.

Summarization of the cellular functions of circRNAs in tumorigenesis of OvCa

CircRNAs	Circbase ID	Role in OvCa	Cancer phenotypes	Sponge miRNAs	Target genes	References
circMUC16	hsa_circ_0049116	Oncogene	Promoted proliferation and invasion	miR-199a-5p	Beclin1/RUNX1	[55]
circCSPP1	hsa_circ_0001806	Oncogene	Promoted proliferation, migration, invasion and EMT	miR-1236-3p	ZEB1	[58]
circEPSTI1	hsa_circ_0000479	Oncogene	Promoted proliferation, invasion and induced apoptosis	miR-942	EPSTI1	[61]
/	hsa_circ_0051240	Oncogene	Promoted proliferation, migration, and invasion	miR-637	KLK4	[62]
circWHSC1	hsa_circ_0001387	Oncogene	Promoted proliferation, migration, invasion, EMT and induced apoptosis	miR-145/miR-1182	MUC1/hTERT	[64]
/	hsa_circ_0061140	Oncogene	Promoted proliferation, invasion and EMT	miR-370	FOXM1	[16]
circHIPK3	hsa_circ_0000284	Tumor suppressor	Inhibited proliferation, migration and invasion and promoted apoptosis	miR-10a-5p/miR-148b	/	[77]
circLARP4	has_circ_101057	Tumor suppressor	Inhibited proliferation and migration	miR-513b-5p	LARP4	[81]
circPLEKHM3	hsa_circ_0001095	Tumor suppressor	Inhibited proliferation and migration	miR-9	BRCA1/NAJB6/KLF4	[82]
CircITCH	/	Tumor suppressor	Inhibited proliferation, migration, invasion and promoted apoptosis	miR-10a-α/miR-145	RASA1	[83, 84]