Table 3.
Summary of differential metabolites between OS and OSC
| Metabolite | 143B | MG63 | |||||
|---|---|---|---|---|---|---|---|
| VIP | P value | FC | VIP | P value | FC | ||
| Amino acid | Prolyl-Threonine | 2.59 | 6.43 × 10−15 | 0.04 | 1.76 | 1.72 × 10−12 | 0.13 |
| S-Methyl-5′-thioadenosine | 2.23 | 3.60 × 10−05 | 1.21 | 3.38 | 5.45 × 10−12 | 2.44 | |
| S-Adenosyl-L-homocysteine | 3.54 | 1.03 × 10−08 | 35.32 | 1.00 | 1.95 × 10−05 | 11.05 | |
| NAAG | 1.06 | 5.40 × 10−07 | 1.61 | 1.42 | 1.92 × 10−08 | 7.63 | |
| Glutathione | 12.13 | 1.11 × 10−14 | 16.90 | 5.25 | 2.69 × 10−08 | 10.60 | |
| Glutathione disulfide | 1.04 | 1.21 × 10−4 | 1.13 | 1.70 | 1.07 × 10−05 | 1.80 | |
| L-Malic acid | 2.71 | 7.98 × 10−10 | 8.12 | 1.73 | 3.57 × 10−09 | 1.53 | |
| N-Acetyl-l-aspartic acid | 3.86 | 7.27 × 10−11 | 3.10 | 4.39 | 3.57 × 10−08 | 1.53 | |
| Harman | 7.24 | 7.07 × 10−09 | 0.66 | 7.57 | 1.08 × 10−11 | 0.39 | |
| Indole-3-carboxylic acid | 1.56 | 7.89 × 10−09 | 29.18 | 1.08 | 2.07 × 10−10 | 15.99 | |
| Fatty acids | Erucic acid | 1.25 | 4.48 × 10−05 | 0.76 | 2.02 | 5.28 × 10−11 | 0.18 |
| Erucamide | 11.38 | 1.41 × 10−05 | 0.71 | 16.66 | 6.28 × 10−10 | 0.14 | |
| Linoleic acid | 3.90 | 2.82 × 10−10 | 7.63 | 2.53 | 4.03 × 10−4 | 4.64 | |
| Stearic acid | 3.78 | 1.54 × 10−07 | 0.63 | 3.89 | 2.15 × 10−10 | 0.48 | |
| Capric acid | 2.57 | 4.40 × 10−09 | 0.62 | 1.77 | 2.32 × 10−08 | 0.66 | |
| Desmosterol | 3.12 | 5.16 × 10−09 | 0.23 | 3.68 | 8.14 × 10−11 | 0.25 | |
| Undecanoic Acid | 1.96 | 2.63 × 10−10 | 0.41 | 1.17 | 5.61 × 10−10 | 0.49 | |
| Stearoylcarnitine | 6.89 | 2.06 × 10−12 | 0.19 | 9.86 | 2.68 × 10−11 | 0.33 | |
| LysoPE(16:0/0:0) | 3.56 | 3.47 × 10−10 | 2.29 | 4.65 | 3.28 × 10−12 | 4.89 | |
| 25-Hydroxycholesterol | 3.23 | 1.12 × 10−08 | 0.21 | 2.24 | 1.51 × 10−09 | 0.15 | |
| LysoPE(18:0/0:0) | 1.73 | 6.86 × 10−11 | 2.91 | 1.44 | 5.23 × 10−11 | 2.48 | |
| LysoPC(16:0) | 13.45 | 2.66 × 10−10 | 1.80 | 14.17 | 1.02 × 10−12 | 3.12 | |
| LysoPC(O-18:0) | 5.87 | 3.91 × 10−12 | 3.21 | 2.07 | 1.50 × 10−07 | 1.23 | |
| SOPC | 3.60 | 6.80 × 10−3 | 0.63 | 4.52 | 2.21 × 10−13 | 0.28 | |
| Phosphorylcholine | 1.58 | 1.63 × 10−09 | 0.25 | 2.97 | 2.93 × 10−13 | 0.07 | |
| 16-Hydroxypalmitic acid | 1.23 | 5.22 × 10−09 | 3.13 | 2.60 | 2.63 × 10−14 | 4.86 | |
| Oleic acid | 1.53 | 4.42 × 10−05 | 1.72 | 2.49 | 4.40 × 10−07 | 2.26 | |
| LysoPE(16:0/0:0) | 4.26 | 1.74 × 10−10 | 2.33 | 8.06 | 1.48 × 10−12 | 3.97 | |
| Retinol | 2.72 | 1.05 × 10−14 | 10.70 | 1.83 | 1.85 × 10−12 | 8.09 | |
| Geranyl diphosphate | 3.51 | 6.76 × 10−13 | 0.03 | 4.06 | 3.83 × 10−16 | 0.02 | |
| Carbohydrates | UDP-d-Glucose | 3.23 | 7.36 × 10−09 | 4.24 | 2.32 | 7.16 × 10−05 | 2.24 |
| d-Fructose 1,6-bisphosphate | 3.38 | 1.98 × 10−06 | 0.13 | 1.35 | 1.08 × 10−07 | 0.49 | |
| Nucleic acid | 2′-O-methylcytidine | 3.92 | 1.37 × 10−11 | 0.26 | 4.05 | 4.73 × 10−14 | 0.11 |
| Adenosine 3′-monophosphate | 4.67 | 9.90 × 10−16 | 13.53 | 2.04 | 8.97 × 10−10 | 7.84 | |
| UDP | 3.86 | 9.19 × 10−10 | 6.38 | 3.11 | 1.14 × 10−09 | 2.26 | |
| UTP | 2.33 | 7.48 × 10−05 | 5.58 | 2.10 | 1.42 × 10−3 | 3.84 | |
| dGTP | 9.72 | 1.21 × 10−05 | 2.47 | 5.47 | 1.90 × 10−2 | 1.32 | |
VIP Variable Importance for the Project, FC fold change, NAAG N-Acetylaspartylglutamate, SOPC 1-Stearoyl-2-oleoyl-sn-glycerol 3-phosphocholine, UDP-d-Glucose Uridine diphosphate glucose, UDP Uridine 5′-diphosphate, UTP Uridine 5′-triphosphate, dGTP deoxyguanosine triphosphate