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. 2020 Mar 27;103(1):24–35. doi: 10.1093/biolre/ioaa036

Figure 3.

Figure 3

Ovarian follicle attrition is significant and pools become depleted by 6 months of age in Chtf18−/− females. Morphometric analyses were performed on sections of paraffin-embedded H&E-stained ovary pairs from Chtf18−/− and wild-type females. Values are the mean ± SEM by the unpaired t-test. (A and B) Numbers of primordial follicle numbers at postnatal day 7 (PND 7) (n = 9 mice/genotype; P = 0.0446*) and postnatal day 21 (PND 21) (n = 8 mice/genotype, P = 0.0049**). (C) Numbers of primordial, primary, secondary, and antral follicles at 3 months, n = 14 mice/genotype (primordial: P = 0.0045**; primary: P = 0.0041**; secondary: P = 0.0048**; and antral: P = 0.1008) and (D) at 6 months (n = 10 mice/genotype) (primordial: P = 0.0254*; primary: P = 0.0014**; secondary: P = 0.0056**; and antral: P = 0.0402*). (E) Bar graph represents the numbers of primordial follicles of wild-type vs. Chtf18−/− ovaries at postnatal days 7 and 21, and at 3 and 6 months of age. Values are the mean ± SEM with numbers of mice and P values stated in A–D.