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Numbers needed to treat (NNT) to obtain benefit and harm of selected analgesics. Benefit is defined as a patient reaching at least 50% of the maximum theoretic total pain relief (TOTPAR) score, which is 16 (50% max = 8) or 24 (50% max = 12) in a 4- or 6-h study, respectively. Harm is defined as a reported or observed side effect. Adapted from data presented by Barden et al. (2004), Derry et al. (2011), and Moore et al. (2015a, 2015b).
