Fig.2.

Effects of acute kynurenine (KYN) administration, with and without PAM-2, on working memory performance in the delay non-match to position (DNMTP) task. Data represent the percentage of correctly completed trials (mean ± SEM), in a single group of rats (n = 8), during three drug sessions (order randomized: vehicle, 100 mg/kg KYN, 100 mg/kg KYN + 1 mg/kg PAM-2). Choice accuracy is depicted for all three delay intervals (5, 10, 15 s). Acute administration of KYN resulted in a reduction in accuracy that interacts with delay length. KYN (100 mg/kg) reduced choice accuracy during the 10 and 15s delay trials but not during 5 s delay trials. Co-administration of PAM-2 (1 mg/kg) prevented the performance deficit caused by KYN (100 mg/kg) during the 10 and 15 s delay trials. Significance is denoted as P < 0.05 (*), P <0.01 (**), and P <0.001 (***)