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. Author manuscript; available in PMC: 2020 Jun 24.
Published in final edited form as: Psychopharmacology (Berl). 2020 Mar 11;237(6):1723–1735. doi: 10.1007/s00213-020-05495-y

Fig. 5.

Fig. 5

Effects of acute kynurenine (KYN) administration, with and without galantamine (GAL), on task omissions in the delay non-match to position (DNMTP) task. Data represent the number of omissions (mean ± SEM), in a single group of rats (n = 7), during four drug sessions (order randomized: vehicle, 25 mg/kg KYN, 100 mg/kg KYN, 100 mg/kg KYN + 3 mg/kg GAL). Acute administration of KYN resulted in a dose-dependent increase in the number of omissions. The high dose (100 mg/kg) but not the low dose (25 mg/kg) of KYN significantly increased omissions compared to vehicle. Treatment with KYN (100 mg/kg) induced an increase in omissions. Co-administration of GAL (3 mg/kg) did not return the number of omissions to control levels despite the fact that accuracy values were normalized (cf. Fig. 1). Significance is denoted as P < 0.0001 (****)