Table 3.
Multivariable Cox regression analyses of predictors of seizures within 7 and 90 days.
| Variables | Any seizure ≤90 d Adjusteda HR (95%CI) | p | Early seizure ≤7 d Adjusteda HR (95%CI) | p |
|---|---|---|---|---|
| Age (years) | 0.98 (0.97–0.99) | 0.004 | 0.98 (0.97–0.99) | 0.008 |
| Sex (male) | 0.96 (0.70–1.30) | 0.77 | 1.01 (0.72–1.40) | 0.98 |
| Premorbid mRS | 1.15 (1.00–1.32) | 0.051 | 1.07 (0.91–1.25) | 0.41 |
| NIHSS | 1.03 (1.01–1.05) | 0.019 | 1.03 (1.01–1.06) | 0.014 |
| Prior stroke/TIA | 1.69 (1.17–2.43) | 0.005 | 1.66 (1.11–2.47) | 0.013 |
| Prior intracerebral haemorrhage | 1.11 (0.65–1.89) | 0.71 | 1.20 (0.68–2.14) | 0.53 |
| Lobar location | 4.83 (3.07–7.60) | <0.001 | 5.84 (3.58–9.52) | <0.001 |
| Baseline haematoma volume (per 10 mL) | 1.07 (0.98–1.17) | 0.13 | 1.07 (0.97–1.17) | 0.16 |
| PHO volume (per 10 mL) | 1.08 (0.87–1.33) | 0.49 | 1.12 (0.90–1.40) | 0.31 |
| Midline shift ≥5 mm | 1.30 (0.85–1.99) | 0.23 | 1.11 (0.69–1.78) | 0.67 |
| Periventricular leukoaraiosis | 1.41 (1.00–1.99) | 0.049 | 1.31 (0.91–1.90) | 0.15 |
| Tranexamic acid | 0.89 (0.66–1.19) | 0.42 | 0.86 (0.62–1.18) | 0.34 |
CI: confidence interval; HR: hazard ratio; mRS: modified Rankin Scale; NIHSS: National Institute of Health Stroke Scale; PHO: perihaematomal oedema; TIA: transient ischaemic attack.
aAdjusted for a priori variables of age, sex and treatment allocation and variables that were significant on univariate analyses.