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. 2020 Jun 17;10:255. doi: 10.3389/fcimb.2020.00255

Figure 2.

Figure 2

Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of the JAK/STAT Pathway in Trypanosoma cruzi-infected myoblasts. The JAK/STAT Pathway obtained from the KEGG platform was used as template to highlight the effect of Brazil (A), CL (B), Tulahuen (C), and Y (D) strain in L6E9 rat myoblasts. Blue boxes indicate significant upregulation (>1.5-fold), and red boxes indicate significant downregulation (<-1.5-fold). Yellow boxes indicate genes that showed no significant alteration in infected vs. control cultures, whereas white boxes indicate genes that were absent in the analysis (i.e., those that for any reason did not match the exclusion criteria; e.g., a positive signal in all four biological replicas of each group). Extracellular ligands such as IL-6 family of cytokines bind to membrane receptors, including IL-3R and IL-21R, which in turn activate members of the JAK/STAT pathway or, alternatively, of the MAPK signaling pathway. STATs translocate to cell nucleus and activate transcription of genes that can activate cell cycle, apoptosis, or cell differentiation.