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. 2020 Jun 17;10:255. doi: 10.3389/fcimb.2020.00255

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Copyright © 2020 Nisimura, Coelho, de Melo, Vieira, Victorino, Garzoni, Spray, Iacobas, Iacobas, Tanowitz and Adesse.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential effects of infection on global gene correlation. Plots of correlation coefficients between the expression levels of the indicated genes with each other genes differentially expressed in each experimental condition. The number of neutral (black bars), positive (blue bars), and negative correlations (yellow bars) was quantified among genes belonging to the JAK/STAT (A) and Cell Cycle (B) pathways. T. cruzi infection increased the number of positive correlations of the JAK/STAT pathway, whereas an opposite effect was observed for Cell Cycle genes. In (C,D) are depicted representative correlation profiles of each pathway: cav-1 and stat3 of the JAK/STAT pathway (C) and YWHAZ and YWHAQ of the Cell Cycle Pathway (D). Profiles of the uninfected controls are represented by the black dots and T. cruzi-infected by red dots.