FIGURE 8.

Predicted scores of peptides eluted off HLA-DRB1*01:01 and HLA-DRB1*03:01 and compared with random peptides. Top, the peptide microarray model prediction of eluted peptides (gray density) are clearly skewed toward high scores whereas random peptides (white density) are primarily skewed toward low scores for both HLA-DR allotypes. Bottom, predicted scores by the models trained in IEDB data presents a similar pattern of eluted peptides (gray density) and random peptides (white density). The model performances are summarized in Table II, showing that HLA-DRB1*03:01 models performed at par, whereas the HLA-DRB1*01:01 model, based on IEDB datasets, had a better prediction power compared with the model trained on peptide microarray data.