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. Author manuscript; available in PMC: 2020 Jun 24.
Published in final edited form as: Eur Respir J. 2019 May 30;53(5):1801291. doi: 10.1183/13993003.01291-2018

Figure 1. Eosinophil-dependent alveolar destruction and modulation of MMP-12.

Figure 1.

(A) H&E stained lung sections demonstrate increased alveolar spaces in I5/hE2 lungs relative to wild type and, their eosinophil deficient counterparts, I5/hE2/PHIL. Lung parenchyma 200x. (B) Quantification of average alveolar space revealed a two-fold increase in mean intercept length in I5/hE2 lungs (panel B, n=5 mice). (C) BAL fluid was collected and assessed by ELISA for MMP-12, a lung remodeling mediator with dramatically increased expression in I5/hE2 lungs (panel C, n=6 mice). Scale bar = 50μm. *:p<0.05. ****:p<0.0001. ns: not significant.