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. Author manuscript; available in PMC: 2020 Jun 24.
Published in final edited form as: Eur Respir J. 2019 May 30;53(5):1801291. doi: 10.1183/13993003.01291-2018

Figure 2. MMP-12 mediates alveolar destruction in I5/hE2 model.

Figure 2.

(A) H&E stained lung sections demonstrate enlarged airspaces in I5/hE2 mice relative to wild type and MMP-12−/− mice. (B) H&E stained lung sections assessed for mean intercept length (Lm) demonstrate increased alveolar spaces in I5/hE2 mice relative to their MMP-12 deficient counterparts I5/hE2/MMP-12−/−. Lung parenchyma 200x. (C). n≥3 mice. Scale bar = 50μm. **: p<0.01, ***:p<0.001, ****:p<0.0001.