Figure 4.

Functional links between isatin-binding proteins specific to the brain hemispheres of isatin-treated mice. Line thickness and type (solid or dashed) reflect combined score and evidence suggesting a functional link. Bold lines indicate direct interactions between the identified proteins, annotated in String (v. 11.0 of January 19, 2019). Bold dashed lines show experimentally proven interactions between the identified proteins. Colors indicate different functional clusterization: red color shows intracellular molecular scaffolds with various intracellular proteins, aquamarine designates proteins involved in regulations of RNA splicing, green color shows enzymes, involved in metabolic processes, blue color shows proteins involved in regulation of neuron-specific proliferation.